A mathematical model for the first-pass dynamics of antibiotics acting on the cardiovascular system

نویسندگان

  • H. T. Banks
  • Kathleen Holm
  • Nathan C. Wanner
  • Ariel Cintrón-Arias
  • Grace M. Kepler
  • Jeffrey D. Wetherington
چکیده

We present a preliminary first-pass dynamic model for delivery of drug compounds to the lungs and heart. We use a compartmental mass balance approach to develop a system of nonlinear differential equations for mass accumulated in the heart as a result of intravenous injection. We discuss sensitivity analysis as well as methodology for minimizing mass in the heart while maximizing mass delivered to the lungs on a first circulatory pass.

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عنوان ژورنال:
  • Mathematical and computer modelling

دوره 50 7-8  شماره 

صفحات  -

تاریخ انتشار 2009